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(Stroke. 2004;35:e97.)
© 2004 American Heart Association, Inc.

Research Report

Race-Specific Relationships Between Coronary and Carotid Artery Calcification and Carotid Intimal Medial Thickness

Lynne E. Wagenknecht, DrPH; Carl D. Langefeld, PhD; J. Jeffrey Carr, MD; Ward Riley, PhD; Barry I. Freedman, MD; Shahriar Moossavi, MD Donald W. Bowden, PhD

From Departments of Public Health Sciences (L.E.W., C.D.L., J.J.C.), Radiology (J.J.C.), Neurology (W.R.), Internal Medicine (B.I.F., S.M.), and Biochemistry (D.W.B.), Wake Forest University School of Medicine, Winston-Salem, NC.

Correspondence to Dr Lynne E. Wagenknecht, Professor, Wake Forest University School of Medicine, Department of Public Health Sciences, Medical Center Blvd, Winston-Salem, NC 27157-1063. E-mail lwgnkcht{at}wfubmc.edu

Background and Purpose— Calcified arterial plaque has been proposed as a subclinical marker of atherosclerosis. We compared it to a well-validated surrogate—carotid intimal medial thickness (IMT).

Methods— Calcified arterial plaque was measured in 2 vascular beds (coronary and carotid) by computed tomography, and common carotid artery IMT was measured by B-mode ultrasonography, in 438 participants.

Results— Calcium was positively associated with IMT (r=0.36 for coronary and r=0.45 for carotid, both P<0.0001). Correlations were attenuated with adjustment for age, sex, and diabetes.

Conclusions— Calcified plaque in the coronary and carotid arteries is moderately associated with subclinical atherosclerosis.

Key Words: epidemiology • ethnicity • coronary • calcification • carotid intimal medial • thickness • atherosclerosis

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