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(Stroke. 2005;36:151.)
© 2005 American Heart Association, Inc.

Research Reports

Endothelial Progenitor Cells During Cerebrovascular Disease

Usman Ghani, PhD; Ashfaq Shuaib, MD, FRCPC, FAHA; Abdul Salam, MSc; Aman Nasir, BSC; Umar Shuaib, BSc; Tom Jeerakathil, MD, FRCPC; Faiz Sher, MD; Fintan O’Rourke, MD, MRCP; Abdul Majeed Nasser, MD; Brenda Schwindt, RN Kathryn Todd, PhD

From Stroke Research (U.G., A.S., A.Sa., U.S., T.J., F.S., F.O., A.M., B.S.), and the Department of Psychiatry Unit (K.T.), Division of Neurology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Correspondence to Prof Ashfaq Shuaib, Division of Neurology, University of Alberta, 8440-112 Street, Edmonton, Alberta, Canada T6G 2B7. E-mail ashfaq.shuaib{at}ualberta.ca

Background and Purpose— Endothelial progenitor cells (EPCs) are associated with endothelial repair after ischemia in cardiac or peripheral circulation. There are no reports of EPCs with cerebrovascular disease. We present our experience with EPCs in patients with cerebrovascular disease.

Summary of Report— EPC counts differed significantly (P<0.001) between stroke patients (acute stroke: median 4.75 and range 0 to 33; stable stroke: median 7.25 and range 0 to 43) and control subjects (median 15.5 and range 4.3 to 50), independent of age. The level of EPCs was significantly correlated with the Framingham coronary risk score (FCRS) (=–0.349; P=0.002).

Conclusions— Similar to cardiac experience, the low EPC levels may play a role in the pathophysiology of cerebrovascular disease.

Key Words: cerebrovascular disorders • endothelial progenitor cells • stroke, acute

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