Published online before print January 13, 2005, doi: 10.1161/01.STR.0000152951.14573.f8
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(Stroke. 2005;36:232.)
© 2005 American Heart Association, Inc.
Letters to the Editor |
Systemic Inflammatory Response Depends on Initial Stroke Severity but Is Attenuated by Successful Thrombolysis
Department of Neurology, Technical University of Munich, Munich, Germany
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
To the Editor:
We read with interest the article by Audebert et al1 concerning inflammatory response in patients with acute ischemic stroke. The authors describe an association between inflammatory parameters and stroke severity, as well as stroke volume measured by cranial computed tomography (CCT) and magnetic resonance imaging. Moreover, they analyzed in more detail the subgroup of patients receiving thrombolysis and found that the inflammatory markers were significantly lower in patients with improvement after recombinant tissue plasminogen activator treatment.
This is an additional important study concerning inflammation in acute stroke and supports other investigations analyzing C-reactive protein (CRP) in acute ischemic stroke.2–5 The largest study up to now was recently published by Di Napoli et al6 and could demonstrate that elevated levels of CRP were related to the risk of new cardiovascular events.
In general, the findings of the recent study corroborate our results concerning the prognostic relevance of early serial CRP measurements in 127 patients with acute ischemic stroke.5 In our study, the first CRP measurement was performed within 12 hours after symptom onset (mean, 5.0 hours). The second CRP measurement was performed within 24 hours after symptom onset (mean, 19.6 hours). The third was performed 24 hours after the second measurement (mean, 43.1 hours). We also determined the lesion volume on diffusion-weighted imaging (DWI) in a subgroup of 43 patients in which the DWI was performed within 12 hours after symptom onset. However, we only observed a significant association between the third CRP value and the DWI lesion
Department of Neurology, University of Munich, Munich, Germany
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