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(Stroke. 2005;36:2012.)
© 2005 American Heart Association, Inc.

Research Reports

Ischemic Stroke Subtypes and Thrombophilia in Young and Elderly Brazilian Stroke Patients Admitted to a Rehabilitation Hospital

Francisco Javier Carod-Artal, MD, PhD; Simone Vilela Nunes, MD; Dalton Portugal, MD; Tania Virginia Fernandes Silva, MD Antonio Pedro Vargas, MD

From the Department of Neurology, the Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brasilia DF Brazil.

Correspondence to Francisco Javier Carod-Artal, MD, PhD, Neurology Department, Sarah Hospital, SMHS Quadra 501 Conjunto A, CEP 7330-150, Brasilia DF, Brazil. E-mail javier{at}bsb.sarah.br

Background and Purpose— We sought to examine ischemic stroke subtypes and prevalence of thrombophilia in Brazilian stroke patients.

Method— A total of 130 consecutive young and 200 elderly stroke patients were studied.

Results— Prevalence of thrombophilia was, respectively: protein S deficiency (11.5% versus 5.5%), protein C deficiency (0.76% versus 1%), resistance to activated protein C (2.3% versus 3.5%), mutation in V Leiden factor (1.5% versus 2%), antithrombin III deficiency (0% versus 0%), lupus anticoagulant (0% versus 0.5%), anticardiolipin antibodies (3% versus 10%; P=0.01), hyperhomocysteinemia (31.5% versus 53.5%; P=0.0001), mutation of the MTHFR gene in homocigosis (10% versus 5%), and heterocigosis (27.6% versus 41.9%; P=0.01).

Conclusion— Prothrombotic conditions were more frequent in stroke of undetermined cause.

Key Words: epidemiology • stroke • thrombophilia • thrombosis