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(Stroke. 2006;37:243.)
© 2006 American Heart Association, Inc.

Research Reports

Reduced Vitamin D in Acute Stroke

Kenneth E. S. Poole, BM, MRCP; Nigel Loveridge, PhD; Peter J. Barker, MSc; David J. Halsall, PhD, MRCPath; Collette Rose; Jonathan Reeve, DM, BSc, FRCP Elizabeth A. Warburton, MA, DM, MRCP

From the Department of Medicine, Addenbrooke’s Hospital, Cambridge, UK.

Correspondence to Kenneth E.S. Poole, Box 157 Department of Medicine, Addenbrooke’s Hospital, Hills Road, Cambridge, UK CB2 2QQ. E-mail kesp2{at}cam.ac.uk

Background and Purpose— Stroke leads to a reduction in bone mineral density, altered calcium homeostasis, and an increase in hip fractures. Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke.

Methods— We compared the serum 25-dihydroxyvitamin D levels of 44 patients admitted to an acute stroke unit with first-ever stroke with results obtained by measuring 96 healthy ambulant elderly subjects every 2 months for 1 year. Statistical Z scores of serum vitamin D were then calculated after seasonal adjustment for the month of sampling.

Results— The mean Z score of vitamin D in acute stroke was –1.4 SD units (95% CI, –1.7, –1.1), with 77% of patients falling in the insufficient range.

Conclusions— Reduced vitamin D was identified in the majority of patients with acute stroke throughout the year and may have preceded stroke. Vitamin D is a potential risk marker for stroke, and the role of vitamin D repletion in enhancing musculoskeletal health after stroke needs to be explored.

Key Words: rehabilitation • stroke

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