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(Stroke. 2006;37:27.)
© 2006 American Heart Association, Inc.

Original Contributions

C-Reactive Protein and Risk of First-Ever Ischemic and Hemorrhagic Stroke in a General Japanese Population

The Hisayama Study

Yoshiyuki Wakugawa, MD; Yutaka Kiyohara, MD, PhD; Yumihiro Tanizaki, MD, PhD; Michiaki Kubo, MD, PhD; Toshiharu Ninomiya, MD, PhD; Jun Hata, MD; Yasufumi Doi, MD, PhD; Ken Okubo, MD; Yoshinori Oishi, MD; Kentaro Shikata, MD; Koji Yonemoto, PhD; Daisuke Maebuchi, MD; Setsuro Ibayashi, MD, PhD Mitsuo Iida, MD, PhD

From the Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Correspondence to Yoshiyuki Wakugawa, MD, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka City 812-8582, Japan. E-mail wakuwaku{at}intmed2.med.kyushu-u.ac.jp

Background and Purpose— The role of high-sensitivity C-reactive protein (hsCRP) in the development of stroke is not clearly understood. We investigated the relationship between serum hsCRP levels and stroke occurrence in a general Japanese population.

Methods— We followed 2692 subjects 40 years of age for 12 years. The relative risks and 95% CIs for ischemic and hemorrhagic stroke occurrence were calculated according to the hsCRP quintiles.

Results— During the follow-up, 129 first-ever ischemic and 59 hemorrhagic strokes occurred. In men, the age-adjusted incidence of ischemic stroke significantly increased with elevated serum hsCRP levels; the difference between the first and fifth quintiles was statistically significant (1.4 versus 6.6 per 1000 person-years; P=0.02). This association remained significant even after adjustment for other confounding factors, such as age, systolic blood pressure, ECG abnormalities, diabetes, body mass index, total cholesterol, high-density lipoprotein cholesterol, smoking habits, alcohol intake, and regular exercise (adjusted relative risks, 3.11; 95% CI, 1.04 to 9.32; P=0.04). However, such associations were not observed for ischemic stroke in women or in hemorrhagic stroke in either sex. Among male subjects who were both in the fifth hsCRP level and had hypertension, diabetes, obesity, hypercholesterolemia, or a smoking habit, the risk of ischemic stroke was extremely increased, even after adjustment for other risk factors.

Conclusions— Our findings suggest that elevated serum hsCRP levels are an independent risk factor for future ischemic stroke in Japanese men and that the coexistence of a high hsCRP level with another risk factor extremely increases the risk of ischemic stroke.

Key Words: C-reactive protein • hemorrhage, brain • ischemic stroke

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