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(Stroke. 2006;37:2473.)
© 2006 American Heart Association, Inc.

Original Contributions

The Unchanging Incidence and Case-Fatality of Stroke in the 1990s

A Population-Based Study

Dawn Kleindorfer, MD; Joseph Broderick, MD; Jane Khoury, MS; Matthew Flaherty, MD; Daniel Woo, MD; Kathleen Alwell, RN; Charles J. Moomaw, MS; Alexander Schneider, MD; Rosie Miller, RN; Rakesh Shukla, PhD Brett Kissela, MD

From the University of Cincinnati, Cincinnati, Ohio.

Correspondence to Dawn Kleindorfer, MD, University of Cincinnati, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267-0525. E-mail Dawn.kleindorfer{at}uc.edu

Background and Purpose— Many advances were made in stroke prevention strategies during the 1990s, and yet temporal trends in stroke incidence and case-fatality have not been reported in the United States. Blacks have a 2-fold higher risk of stroke; however, there are no data over time showing if any progress has been made in reducing racial disparity in stroke incidence. The objective of this study was to examine temporal trends in stroke incidence and case-fatality within a large, biracial population during the 1990s.

Methods— Within a biracial population of 1.3 million, all strokes were ascertained at all local hospitals using International Classification of Diseases, 9th Revision codes during July 1993 to June 1994 and again in 1999. A sampling scheme was used to ascertain cases in the out-of-hospital setting. Race-specific incidence and case-fatality rates were calculated and standardized to the 2000 US Census population. A population-based telephone survey regarding stroke risk factor prevalence and medication use was performed in 1995 and 2000.

Results— There were 1954 first-ever strokes in 1993–1994 and 2063 first-ever strokes in 1999. The annual incidence of first-ever hospitalized stroke did not significantly change between study periods: 158 per 100 000 in both 1993–1994 and 1999 (P=0.97). Blacks continue to have higher stroke incidence than whites, especially in the young; however, case-fatality rates continue to be similar between races and are not changing over time. Medication use for treatment of stroke risk factors significantly increased in the general population between study periods.

Conclusions— Despite advances in stroke prevention treatments during the 1990s, the incidence of hospitalized stroke did not decrease within our population. Case-fatality also did not change between study periods. Excess stroke mortality rates seen in blacks nationally are likely the result of excess stroke incidence and not case-fatality, and the racial disparity in stroke incidence did not change over time.

Key Words: epidemiology • incidence • stroke

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