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(Stroke. 2006;37:1120.)
© 2006 American Heart Association, Inc.

Research Reports

The Risks and Safety of Clopidogrel in Pediatric Arterial Ischemic Stroke

Teesta Soman, MD; Mubeen F. Rafay, MB, BS; Selina Hune, MSc, NP; Anita Allen, RN; Daune MacGregor, MD Gabrielle deVeber, MD

From the Hospital for Sick Children, Toronto, Canada.

Correspondence to Dr Gabrielle deVeber, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8. E-mail Gabrielle.deveber{at}sickkids.ca

Background and Purpose— The purpose of this study was to determine safety and tolerability of clopidogrel in children with arterial ischemic stroke (AIS). Clopidogrel is the alternative antiplatelet medication when aspirin is not tolerated or fails. The possible risks and safety of clopidogrel in children with AIS have not been assessed.

Methods— This is a prospective consecutive cohort study of children with AIS who were started on clopidogrel. Seventeen children were included.

Results— Two children developed subdural hematomas while on clopidogrel in conjunction with aspirin. Two others had headache or hand numbness. No other side effects like rash or gastrointestinal upsets were reported.

Conclusions— We found clopidogrel to be relatively well tolerated in the pediatric population. In combination with aspirin and in the presence of other risk factors, intracranial bleeding may be seen.

Key Words: antiplatelet agents • child • clopidogrel • stroke

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