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(Stroke. 2006;37:1578.)
© 2006 American Heart Association, Inc.

Special Report

Recommendations of the National Heart, Lung, and Blood Institute Working Group on Cerebrovascular Biology and Disease

Costantino Iadecola, MD; Stephen S. Goldman, PhD; David R. Harder, PhD; Donald D. Heistad, MD; Zvonimir S. Katusic, MD, PhD; Michael A. Moskowitz, MD; J. Marc Simard, MD, PhD; Michael A. Sloan, MD; Richard J. Traystman, PhD Paul A. Velletri, PhD

From the Weill Cornell Medical College, New York, NY (C.I.); the National Heart, Lung, and Blood Institute, Bethesda, MD (S.S.G., P.A.V.); Medical College of Wisconsin, Milwaukee, WI (D.H.); University of Iowa, Iowa City, IA (D.D.H.); Mayo Clinic College of Medicine, Rochester, MN (Z.S.K.); Massachusetts General Hospital, Charlestown, MA (M.A.M.), University of Maryland Medical School, Baltimore, MD (J.M.S.); Carolinas Medical Center, Charlotte, NC (M.A.S.); Oregon Health and Science University School of Medicine, Portland, OR (R.J.T.).

Correspondence to Stephen S. Goldman, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, MSC 7956, Suite 10192, Bethesda, MD, United States 20892. E-mail goldmans{at}nhlbi.nih.gov

The National Heart, Lung, and Blood Institute (NHLBI) convened a conference call working group, consisting of experts in stroke and cerebrovascular biology on January 28, 2005. The purpose of this working group was to develop a prioritized set of recommendations for NHLBI to establish a focused and comprehensive set of research activities in cerebrovascular biology and disease. Three thematic areas of research emerged: (1) molecular and cellular neurobiology of cerebral blood vessels, focusing on genomics and proteomics, neurovascular signaling and cerebrovascular embryogenesis, development and plasticity; (2) resource development, involving the development of new methodological approaches for normal and altered function of the neurovascular unit, collaborative research, and training in cerebrovascular pathobiology; and (3) cerebrovascular diseases and translational approaches, addressing vascular mechanisms of disease, the role of risk factors, importance of biomarkers with the ultimate goal of developing new treatments.

Key Words: cerebrovascular disease • microcirculation

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