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(Stroke. 2007;38:1167.)
© 2007 American Heart Association, Inc.

Original Contributions

Blood Pressure and Estimated Risk of Stroke in the Elderly Population of Spain

The PREV-ICTUS Study

Josep Redón, PhD; Luis Cea-Calvo, MD; José V. Lozano, MD; Juan C. Martí-Canales, MD; José L. Llisterri, MD; Jose Aznar, MD; Jorge González-Esteban, MD on behalf of the investigators of the PREV-ICTUS study

From Hypertension Unit (J.R.), Hospital Clínico Universitario, Universidad de Valencia, Valencia Spain; Clinical Research Department (L.-C.C., J.G.-E.), Merck Sharp & Dohme de España, Madrid, Spain; Serrería 2 Health Center (J.V.L.), Valencia, Spain; Orcera Health Center (J.C.M.-C.), Jaen, Spain; Ingeniero Joaquín Benlloch Health Center (J.L.L.), Valencia, Spain; Research Unit (J.A.), Hospital Marina Alta, Denia, Spain.

Correspondence to Josep Redón, MD, Hypertension Clinic. Internal Medicine, Hospital Clinico, University of Valencia, 46010 Valencia. Spain. E-mail josep.redon{at}uv.es

Background and Purpose— The objective of this study was to estimate the high blood pressure values and the 10-year risk of stroke in the Spanish general population aged 60 years or older using the Framingham scale.

Methods— This was a multicenter, population-based, cross-sectional study performed in Spanish primary care centers. A randomized selection of centers and recruitment population was used. We collected clinical, biochemical, and electrocardiographic data.

Results— We analyzed 7343 subjects (mean age, 71.6 years; standard deviation, 7.0; 53.4% females, 34.4% obese subjects, and 27.1% diabetic subjects). Electrocardiographic–left ventricle hypertrophy was present in 12.9% of the subjects, atrial fibrillation in 8.4%, and established cardiovascular disease in 28.9%; 73.0% already had hypertension diagnosed, and 12.8% showed high blood pressure without a prior diagnosis of hypertension. Among hypertensive subjects, 29.1% had high blood pressure on therapeutic objective, and of the total population 35.7% had high blood pressure under control. Those with hypertension already diagnosed showed a higher prevalence of other stroke risk factors (left ventricle hypertrophy, atrial fibrillation, diabetes, or established cardiovascular disease). The estimated 10-year stroke risk was 19.6% (standard deviation, 17.3%), and was greater in hypertensive patients (23.7%; standard deviation, 18.5) than in patients with high blood pressure without known hypertension (12.4%; standard deviation, 9.2), or in normotensive subjects (5.3%; standard deviation, 0.2; P<0.001).

Conclusion— The 10-year estimated stroke risk was 19.6%, and it was greater in hypertensive patients as compared with the remainder people at any blood pressure range. The concomitant stroke risk factors are more prevalent in patients with hypertension already diagnosed, which implies an important additional estimated risk of stroke.

Key Words: blood pressure • elderly • hypertension • risk factors • stroke