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(Stroke. 2007;38:e23.)
© 2007 American Heart Association, Inc.

Letters to the Editor

GPx-3 Gene Promoter Variation and the Risk of Arterial Ischemic Stroke

Neurology Department, University of Heidelberg, Heidelberg, Germany

Alessandro Padovani, MD Alessandro Pezzini, MD

Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy

An extract of the first 250 words of the full text is provided, because this article has no abstract.

To the Editor:

The recently published association of a particular promoter variant of the GPx-3 (plasma glutathione peroxidase) gene with increased risk for arterial ischemic stroke in this journal¹ was the result of a long-duration research project. A set of linked polymorphisms in the promotor of the GPx-3 gene was described previously, and it was shown that carriers of a particular haplotype (H₂) had a 2-fold increase in risk of ischemic stroke compared with noncarriers.² The authors had, furthermore, analyzed the regulation of GPx-3 expression in a cultured cell system, identified a novel transcription start site and demonstrated that hypoxia was a strong transcriptional regulator of GPx-3 expression.³ The interest of the research group in GPx-3 was raised by their initial discovery of decreased plasma glutathione peroxidase activity in familial childhood stroke.⁴

The novel investigations extended these findings in several ways: 8 single nucleotide polymorphisms (SNP) were identified in the 5'end flanking region as well as 8 promoter haplotypes. The association of the H₂ haplotype with an increased risk of arterial ischemic stroke (AIS) was demonstrated in an enlarged series of 123 young adults, compared with 123 control subjects. The association was confirmed in a second independent population with childhood stroke (82 patients and 82 control subjects).¹

These promising results lead us to analyze the GPx-3 promoter in 2 populations of young stroke patients (<50 years) in order to confirm these results in a replica study. The H₂ haplotype was tagged with the –65 T/C SNP as well as . . . [Full Text of this Article]

This article has been cited by other articles:

				C. Grond-Ginsbach, M.-L. Arnold, C. Lichy, A. Grau, and K. Reuner No Association of the Plasma Glutathione Peroxidase (GPx-3) Gene With Cerebral Venous Thrombosis in the German Population Stroke, February 1, 2009; 40(2): e24 - e24. [Full Text] [PDF]