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(Stroke. 2008;39:2046.)
© 2008 American Heart Association, Inc.

Original Contributions

Vascular Subcortical Hyperintensities Predict Conversion to Vascular and Mixed Dementia in MCI Patients

Stéphanie Bombois, MD, PhD; Stéphanie Debette, MD; Amélie Bruandet, MD; Xavier Delbeuck, PhD; Christine Delmaire, MD, PhD; Didier Leys, MD, PhD Florence Pasquier, MD, PhD

From the Department of Neurology, EA 2691, Memory Center (S.B., S.D., X.D., F.P.) and Stroke unit (S.D., D.L.), and the Department of Neuroradiology (C.D.), Lille University Hospital; and Inserm Unit U744, Pasteur Institute of Lille (A.B.), France.

Correspondence to Pr Pasquier, Department of Neurology, University Hospital 59037 Lille, France. E-mail pasquier{at}chru-lille.fr

Background and Purpose— Patients with mild cognitive impairment (MCI) have an increased risk of dementia. The identification of predictors of conversion to dementia is therefore important. The aim of our study was to test the hypothesis that subcortical hyperintensities (SH) are associated with an increased rate of conversion to dementia in MCI patients.

Methods— This was an observational study on consecutive MCI patients attending a memory clinic. We assessed SH on a baseline MRI scan, using a semiquantitative rating scale. A multivariable Cox regression model was used to test the association of SH with conversion to dementia.

Results— We included 170 MCI patients. The median duration of follow-up was 3.8 years. During this period, 67 patients (39.4%, 95% CI: 32.1 to 46.8%) developed dementia: Alzheimer disease (AD) in 29 patients, dementia with Lewy bodies in 19, mixed dementia in 8, vascular dementia in 7, fronto-temporal dementia in 2, and primary progressive aphasia in 2. SH were not associated with the risk to develop dementia as a whole, including AD. However, the risk to develop vascular or mixed dementia increased significantly with increasing amounts of SH at baseline (HR=1.14 [95% CI: 1.06 to 1.24]), especially periventricular hyperintensities (HR=2.71 [95% CI: 1.60 to 4.58]), independently of medial temporal lobe atrophy, age, gender, vascular risk factors, education, and cognitive functions at baseline.

Conclusion— The risk of vascular or mixed dementia, but not of other types of dementia, was significantly increased in MCI patients with a large amount of subcortical hyperintensities at baseline.

Key Words: mild cognitive impairment • subcortical vascular lesions • conversion • vascular dementia • Alzheimer disease