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(Stroke. 2009;40:S143.)
© 2009 American Heart Association, Inc.

Stem Cell Therapy

Mechanisms Underlying Improved Recovery of Neurological Function After Stroke in the Rodent After Treatment With Neurorestorative Cell-Based Therapies

From the Department of Neurology (M.C., Y.L., Z.G.Z.), Henry Ford Hospital, Detroit; and the Department of Physics (M.C.), Oakland University, Rochester, Mich.

Correspondence to Michael Chopp, PhD, Neurology Department, Research Division, Education and Research Building, Room 3056, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202. E-mail chopp{at}neuro.hfh.edu

We discuss the mechanisms of action underlying the beneficial effects of treating ischemic stroke in the rodent with exogenously administered cells. The essential hypothesis proposed is that the administered cells enhance recovery of neurological function by stimulating the production of restorative factors by parenchymal cells. These activated endogenous brain cells evoke white matter remodeling in the brain and the spinal cord and generate microenvironments within the injured brain that amplify brain plasticity and lead to improvement in neurological function poststroke.

Key Words: stroke • cell-based therapies • mechanisms • neurological function