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(Stroke. 2009;40:S88.)
© 2009 American Heart Association, Inc.

Brain Hemorrhage

Thrombin and Brain Recovery After Intracerebral Hemorrhage

Ya Hua, MD; Richard F. Keep, PhD; Yuxiang Gu, MD, PhD Guohua Xi, MD

From the Department of Neurosurgery, University of Michigan, Ann Arbor, Mich.

Correspondence to Guohua Xi, MD, R5018 Biomedical Science Research Building, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200. E-mail guohuaxi{at}umich.edu

Intracerebral hemorrhage (ICH) is a common and often fatal subtype of stroke and produces severe neurological deficits in survivors. At present, there is lack of effective treatments that improve outcome in ICH. A neglected aspect of ICH research is the development of approaches that can be effectively used to improve recovery. Although previous studies have showed that thrombin induces blood-brain barrier leakage, brain edema, and neuronal death after ICH, our recent studies have shown that thrombin may have a role in brain recovery after ICH. An understanding of the mechanisms by which thrombin affects neurogenesis, angiogenesis, and plasticity may facilitate brain recovery after ICH.

Key Words: angiogenesis • cerebral hemorrhage • neurogenesis • plasticity • thrombin