This Article Free upon publication Full Text Full Text (PDF) All Versions of this Article: 40/4/1148    most recent STROKEAHA.108.539700v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tiel Groenestege, A. T. Articles by Klijn, C. J.M. Search for Related Content PubMed PubMed Citation Articles by Tiel Groenestege, A. T. Articles by Klijn, C. J.M. Pubmed/NCBI databases Medline Plus Health Information Childbirth High Risk Pregnancy Postpartum Care Related Collections Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage

(Stroke. 2009;40:1148.)
© 2009 American Heart Association, Inc.

Go Red for Women

The Risk of Aneurysmal Subarachnoid Hemorrhage During Pregnancy, Delivery, and the Puerperium in the Utrecht Population

Case-Crossover Study and Standardized Incidence Ratio Estimation

Andreas T. Tiel Groenestege, MSc; Gabriel J.E. Rinkel, MD; Johanna G. van der Bom, MD; Ale Algra, MD Catharina J.M. Klijn, MD

From the Department of Neurology (A.T.T.G., G.J.E.R., A.A., C.J.M.K.), Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands; the Department of Clinical Epidemiology (A.A.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; and the Department of Clinical Epidemiology (J.G.v.d.B., A.A.), Leiden University Medical Center, Leiden, The Netherlands.

Correspondence to Catharina J.M. Klijn, MD, Department of Neurology, G03.225, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. E-mail c.j.m.klijn{at}umcutrecht.nl

Background and Purpose— It is unclear whether the risk of aneurysmal subarachnoid hemorrhage (aSAH) is increased during pregnancy, labor, and the puerperium. We compared the risk of aSAH during this period with the risk outside this period.

Methods— We included women with aSAH between 18 and 42 years of age (n=244) from our prospectively collected database of patients with subarachnoid hemorrhage treated in the University Medical Center Utrecht, the provincial referral center, between January 1987 and April 2006. We estimated the relative risk of aSAH during pregnancy, delivery, or the puerperium by a case-crossover design and calculated a standardized incidence ratio, dividing the observed number of patients with aSAH during pregnancy, delivery, or puerperium by the expected number based on the incidence in the general population of women of the same age during the study period.

Results— Of the 244 women, 4 were pregnant, 3 in the puerperium and none in labor. The relative risk of aSAH during pregnancy, delivery, or the puerperium was 0.4 (95% CI, 0.2 to 0.9). Based on the number of women aged 18 to 42 years within the catchment area of our hospital and the number of pregnancies within the study period, the expected number of patients with aSAH during pregnancy, delivery, or the puerperium was 12, resulting in a standardized incidence ratio of 0.6 (95% CI, 0.2 to 1.1).

Conclusions— The risk of aSAH is not increased during pregnancy, labor, and the puerperium. There is no need to advise against pregnancy in women with an increased risk of subarachnoid hemorrhage and no evidence to advise against vaginal delivery in such women.

Key Words: aneurysms • epidemiology • postpartum • pregnancy • SAH