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(Stroke. 2009;40:2578.)
© 2009 American Heart Association, Inc.

Research Letters

Coated-Platelet Levels Are Low in Patients With Spontaneous Intracerebral Hemorrhage

Calin I. Prodan, MD; Andrea S. Vincent, PhD; Rajiv Padmanabhan, MD George L. Dale, PhD

From the Departments of Neurology (C.I.P., R.P.) and Medicine (G.L.D.), University of Oklahoma Health Sciences Center, the Center for the Study of Human Operator Performance (A.S.V.), University of Oklahoma, Norman, and Veterans Affairs Medical Center (C.I.P.), Oklahoma City.

Correspondence to Calin I. Prodan, MD, 711 SL Young Blvd, PPOB, Suite 215, Oklahoma City, OK 73104. E-mail calin-prodan{at}ouhsc.edu

Background and Purpose— Coated-platelets are a subset of platelets with high procoagulant potential observed on dual agonist stimulation with collagen and thrombin. Failure to produce coated-platelets in animals results in a bleeding diathesis. With this background, we undertook a pilot study to investigate coated-platelet production in patients with spontaneous intracerebral hemorrhage (SICH).

Methods— Coated-platelet levels were determined in 26 patients with a diagnosis of SICH and 52 controls.

Results— The patient population had significantly lower coated-platelet levels than the controls (mean±SD, 24.8±9.7% versus 32.9±12.6%, P=0.0035).

Conclusions— Decreased coated-platelet synthesis may be linked to the mechanisms involved in the events leading to SICH.

Key Words: platelets • hemorrhage • intracerebral