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Stroke. 1974;5:226-229

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(Stroke. 1974;5:226.)
© 1974 American Heart Association, Inc.

Effect of Anoxia on Protein Metabolism in Subcellular Fractions of Rabbit Brain

TAKEHIKO YANAGIHARA M.D.1

1 Department of Neurology and the Cerebrovascular Clinical Research Center, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901

The effect of cerebral anoxia on leucine incorporation into proteins of various subcellular fractions from rabbit brain was studied by using a previously reported in vitro model. Although the decrease in leucine incorporation was observed earlier in nuclei and microsomes, other fractions also demonstrated a rapid decrease. These results were quite different from the pattern of leucine incorporation observed in a type of reversible suppression produced with diphenylhydantoin.


Key Words: brain slices • in vitro model • leucine incorporation






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