This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by PANNIER, J. L. Articles by LEUSEN, I. Search for Related Content PubMed PubMed Citation Articles by PANNIER, J. L. Articles by LEUSEN, I.

(Stroke. 1974;5:324.)
© 1974 American Heart Association, Inc.

---

The Influence of Nonrespiratory Alkalosis on Cerebral Blood Flow in Cats

J. L. PANNIER M.D.¹; G. DEMEESTER M.S.¹; I. LEUSEN M.D.¹

¹ Laboratory of Normal and Pathological Physiology, University of Ghent, De Pintelaan 135, B-9000, Ghent, Belgium

Cerebral blood flow was measured with the ¹³³Xenon clearance method during short-lasting (20 minutes) and more prolonged (90 minutes) infusions of Na₂CO₃ solutions in anesthetized cats under controlled ventilation. The infusion protocol was regulated so as to produce a given increase in the plasma [HCO₃^-] in the first 15 minutes, followed by a constant high plasma level for the rest of the infusion period. A high Paco₃ level was induced before and at the end of the infusion, when prolonged infusions were made. The results indicate that, in acute experiments (20 minutes), an increase in plasma [HCO₃^-] of 14 mEq/l does not influence CBF. During more prolonged infusions (90 minutes), an increase of 12 mEq/l produces a reduction of CBF and an increase in the CSF [HCO₃^-]. These changes are more pronounced when the increase in plasma [HCO₃^-] is more marked (18 mEq/l).

Key Words: hypercapnia • ¹³³Xenon • metabolic alkalosis • pH regualtion of CBF