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(Stroke. 1974;5:334.)
© 1974 American Heart Association, Inc.

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Segmented Middle Cerebral Artery Occlusion in Primates: An Experimental Method Requiring Minimal Surgery and Anesthesia

G. F. MOLINARI M.D.¹; J. I. MOSELEY M.D.¹; J. P. LAURENT M.D.¹

¹ Sections on Head Injury and Stroke, Applied Neurologic Research Branch, Collaborative and Field Research, National Institute of Neurological Diseases and Stroke, and the Armed Forces Radiobiology Research Institute, Defense Nuclear Agency, Bethesda, Maryland

Due to certain anthropomorphic features of the cerebral circulation, monkeys are generally preferable to lower species in experimental models of stroke. By injecting specially molded silicone cylinders through internal carotid artery cannulas, segmental occlusions of the middle cerebral artery were produced in macaques. This embolic method produced cerebral infarction in all instances while the integrity of skull and intracranial collateral circulation were preserved. Because only neck surgery was required, local anesthesia could be used, permitting observation of acute infarctions in sedated, conscious animals.

Note:

National Institutes of Health, Building 36, Room 4A03, Bethesda, Maryland 20014.

Key Words: primate stroke model • local anesthesia • embolic method

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