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(Stroke. 1974;5:477.)
© 1974 American Heart Association, Inc.

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Acute Canine Cerebral lschemia: A Preliminary Model to Evaluate Microvascular Mammary-Carotid Anastomosis

CARROLL P. OSGOOD M.D.¹; MANUEL DUJOVNY M.D.¹; HOWARD WISOTZKEY M.D.¹

¹ Department of Neurological Surgery, University of Pittsburgh School of Medicine, Presbyterian-University Hospital, 3550 Terrace Street, and the Oakland Veterans Administration Hospital, University Drive, Pittsburgh, Pennsylvania 15213

Reprint requests to Dr. Carroll P. Osgood, Oakland Veterans Administration Hospital, University Drive, Pittsburgh, Pennsylvania 15213.

Although the dog remains the standard surgical laboratory animal, its extensive collateral circulation makes complete interruption of cerebral blood flow quite difficult. A simple yet reliable canine model for the study of cerebrovascular insufficiency would seem desirable. We have found that complete division of the left subclavian and right brachiocephalic arteries and their major branches can be rapidly performed through a small left thoracotomy. This interruption of blood supply is incompatible with resumption of normal respiratory function, consciousness, or survival, and can be used to evaluate extra-anatomic grafts or anastomoses.

Key Words: hypertension • hyperventilation • decerebration