Stroke, Vol 9, 133-136, Copyright © 1978 by American Heart Association
PR Urquilla
Uridine 5'-triphosphate (UTP) induced long-lasting contractions of isolated
human brain arteries; contractions without decrement were observed for
periods of up to 20-24 hours at which time the tissues were relaxed in a
dose-dependent manner by theophylline. In some vessels, rhythmic
oscillations accompanied the prolonged elevation in tension. In canine
middle cerebral arteries, UTP produced dose related contractions within the
dose range of 1.7 X 10(-6) to 1.7 X 10(-4) M; these responses were
unaffected by methysergide 2.8 X 10(-7) M, phenoxybenzamine 2.9 X 10(-5) M
or indomethacin 9.8 X 10(-6) M, suggesting that the UTP mechanism of action
is probably independent of tryptaminergic or alpha adrenergic receptor
activation, or of prostaglandin biosynthesis. The ability of UTP to produce
prolonged contraction of cerebral vessels, thus, provides an in vitro
preparation in which it is possible to study some of the basic mechanisms
that are associated with cerebral vasospasm.
ARTICLES
Prolonged contraction of isolated human and canine cerebral arteries induced by uridine 5'-triphosphate
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