This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Linder, M. Articles by Alksne, J. F. Search for Related Content PubMed PubMed Citation Articles by Linder, M. Articles by Alksne, J. F.

Stroke, Vol 9, 472-477, Copyright © 1978 by American Heart Association

ARTICLES

Prevention of persistent cerebral smooth muscle contraction in response to whole blood

M Linder and JF Alksne

Using an in vitro system designed to measure arterial constriction, we have demonstrated the importance of platelet function in maintaining cerebral smooth muscle contraction after whole blood injection. We tested two agents, acetyl salicylic acid (ASA) and phthalazinol, both known to interfere with platelet function. In control tests normal rabbit and monkey blood produced a reliable and persistent arterial constriction. In experimental tests blood drawn from animals premedicated with ASA and phthalazinol failed to produce a persistent contraction. These results support the hypothesis that chemicals released during platelet aggregation may be important in persistent vasospasm.

This article has been cited by other articles:

				M. Dhiwakar, N. A. Khan, and L. G. McClymont Surgical resection of cutaneous head and neck lesions: does aspirin use increase hemorrhagic risk? Arch Otolaryngol Head Neck Surg, November 1, 2006; 132(11): 1237 - 1241. [Abstract] [Full Text] [PDF]