Published Online
on May 17, 2007

A more recent version of this article appeared on June 1, 2007

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Submitted on November 11, 2006
Accepted on December 11, 2006

Clinical Significance of Microbleeds in Subcortical Vascular Dementia

Sang Won Seo MD; Byung Hwa Lee MA; Eun-Joo Kim MD, PhD; Juhee Chin MA; Yoon Sun Cho MS; Uicheul Yoon PhD; and Duk L. Na MD, PhD^*

From the Department of Neurology (S.W.S., B.H.L., E.-J.K., J.C., Y.S.C., D.L.N.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; and the Department of Biomedical Engineering (U.Y.), Hanyang University, Seoul, South Korea.

^* To whom correspondence should be addressed. E-mail: dukna{at}smc.samsung.co.kr.

Background and Purpose--Despite many studies investigating the association between the ischemic changes and cognitive impairment in subcortical vascular dementia (SVaD), few studies correlated cognitive impairment with microbleeds (MBs) frequently seen in SVaD.

Methods--Participants consisted of 86 patients with SVaD who fulfilled the criteria proposed by Erkinjuntti et al.

Results--MBs occurred in 73 of 86 (84.9%) patients with SVaD. MBs were most commonly distributed in the cortex, and the cortical MBs were most pronounced in the temporoparietal area. A multiple regression showed that the number of cerebral MB was an independent predictor of cognitive impairment in multiple domains and the severity of dementia even after controlling confounding factors such as age, education, ischemic severity, and number of lacunes.

Conclusion--These results indicate that cerebral MB is one of the important factors that cause cognitive impairments in SVaD.

Key words: cognitive impairment • microbleeds • vascular dementia

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