Published Online
on August 30, 2007

A more recent version of this article appeared on October 1, 2007

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Submitted on March 5, 2007
Accepted on March 20, 2007

Magnetic Resonance Spectroscopy Study of Oxygen Therapy in Ischemic Stroke

Aneesh B. Singhal MD^*; Eva Ratai PhD; Thomas Benner PhD; Mark Vangel PhD; Vallent Lee BA; Walter J. Koroshetz MD; Pamela W. Schaefer MD; A. Gregory Sorensen MD; and R. Gilberto Gonzalez MD, PhD

From the Departments of Neurology (A.B.S., W.J.K.), and Radiology (E.R., T.B., M.V., V.L., P.W.S., A.G.S., R.G.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass.

^* To whom correspondence should be addressed. E-mail: asinghal{at}partners.org.

Background and Purpose—Recent studies suggest that normobaric oxygen therapy (NBO) is neuroprotective in acute ischemic stroke.

Methods—We performed multivoxel magnetic resonance spectroscopic imaging and diffusion/perfusion MRI in patients with stroke treated with NBO or room air. Imaging was performed before, during, and after therapy.

Results—Voxel-based analysis showed excellent correlation between apparent diffusion coefficient values, lactate, and N-acetyl-aspartate levels at all time points. Lactate decreased during NBO and increased post-NBO. N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients.

Conclusion—These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain.

Key words: diffusion-weighted magnetic resonance imaging • neuroprotection • oxygen therapy • proton magnetic resonance spectroscopic imaging • stroke

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