on October 25, 2007
Published online before print October 25, 2007, doi: 10.1161/STROKEAHA.107.491621
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on April 19, 2007
From Department of Neurology (J.-M.L., E.R.G., K.Y., P.Y.), Department of Radiology (K.D.V.), Washington University School of Medicine, St. Louis, Mo; Department of Radiology (Q.L., W.L.), University of North Carolina at Chapel Hill, NC; Topnotch Stroke Center (C.Y.H.), Taipei Medical University, Taipei, Taiwan; Department of Radiology (G.Z.), University of Chicago, Chicago, Ill. * To whom correspondence should be addressed. E-mail: weili_lin{at}med.unc.edu.
Background and Purpose—Stroke-prone spontaneous hypertensive rats (SHRsp) fed a high-salt diet develop malignant hypertension, blood–brain barrier breakdown, and spontaneous intracerebral hemorrhage (ICH). The precise spatial and temporal relationship between these events has not been well-delineated. Methods—Ten SHRsp male rats, fed a high-salt diet, were imaged weekly using MRI, starting at 12 weeks of age. T1-weighted (with and without Gd), T2-weighted, and T2* sequences were acquired. Permeability maps were calculated. Results—Seven SHRsp rats had spontaneous ICH develop before death. Five of the 7 rats had focally increased vascular permeability at the site of the ICH; 3 of these rats had vascular permeability 1 to 2 weeks before spontaneous ICH. Conclusions—Salt-loaded SHRsp rats have increased vascular permeability up to 2 weeks before ICH, predicting hemorrhage both in space and time. These results suggest that hypertensive ICH is preceded by focal vasculopathy detectable by Gd leak.
Revised on May 11, 2007
Accepted on May 18, 2007
Vascular Permeability Precedes Spontaneous Intracerebral Hemorrhage in Stroke-Prone Spontaneously Hypertensive Rats
Jin-Moo Lee MD, PhD;
Key words: hypertension • intracerebral hemorrhage • MRI