Published Online
on January 31, 2008

A more recent version of this article appeared on March 1, 2008

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Submitted on June 19, 2007
Revised on July 18, 2007
Accepted on August 14, 2007

Fibrinogen ’ in Ischemic Stroke. A Case-Control Study

Elim Y.L. Cheung MSc; Shirley Uitte de Willige PhD; Hans L. Vos PhD; Frank W.G. Leebeek MD, PhD; Diederik W.J. Dippel MD, PhD; Rogier M. Bertina PhD; and Moniek P.M. de Maat PhD^*

From the Departments of Hematology (E.Y.L.C., F.W.G.L., M.P.M.M.), and Neurology (D.W.J.D.), Erasmus University Medical Center, Rotterdam; and The Haemostasis and Thrombosis Research Center (S.U.W., H.L.V., R.M.B), Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

^* To whom correspondence should be addressed. E-mail: m.demaat{at}erasmusmc.nl.

Background and Purpose—To determine the contribution of fibrinogen ’ levels and FGG haplotypes to ischemic stroke.

Methods—Associations between fibrinogen ’ levels, fibrinogen ’/total fibrinogen ratio, and FGG haplotypes with the risk of ischemic stroke were determined in 124 cases and 125 controls.

Results—Fibrinogen ’/total fibrinogen ratio was higher in patients than in controls during the acute phase of the stroke and lower in the convalescent phase 3 months after the stroke. FGG haplotype 3 (H3) was associated with a reduced risk of ischemic stroke (odds ratio 0.60; 95% CI, 0.38 to 0.94), but not with the fibrinogen ’/total fibrinogen ratio. In contrast, FGG-H2 was associated with a decreased fibrinogen ’/total fibrinogen ratio, but not with risk of stroke.

Conclusions—Fibrinogen ’/total fibrinogen ratio is associated with ischemic stroke, especially in the acute phase of the disease. In addition, FGG-H3 haplotype appears to be protective against ischemic stroke.

Key words: FGG haplotypes • fibrinogen ’/total fibrinogen ratios • ischemic stroke

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