on January 29, 2009
Published online before print January 29, 2009, doi: 10.1161/STROKEAHA.107.510800
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Submitted on November 27, 2007
From the Department of Neurology (T.F., A.G., M.D.), Ludwig-Maximilians-Universität, Klinikum Grosshadern, Munich, Germany; the Centre for Clinical Neuroscience (S.B., H.S.M.), St. George's, University of London, UK; Max-Planck-Institute of Psychiatry (S.R., B.M.-M.), Munich, Germany; the Institute of Human Genetics (P.L., T.M.), HelmholtzZentrum münchen, Munich/Neuherberg, Germany; the Institute of Epidemiology (H.-E.W.), HelmholtzZentrum münchen, Munich/Neuherberg, Germany; IBE, Chair of Epidemiology (H.-E.W.), Ludwig-Maximilians-Universität, Munich, Germany; and the Institute of Human Genetics (T.M.), Technical University Munich, Germany. * To whom correspondence should be addressed. E-mail: tobias.freilinger{at}med.uni-muenchen.de.
Background and Purpose—Several genes involved in the lymphotoxin- Methods—Twenty-three single nucleotide polymorphisms (SNPs) from LTA, LGALS2, and PSMA6 were genotyped in 601 German IS patients and 736 matched controls. SNPs and haplotypes were tested for association with overall IS, large vessel stroke, and cardioembolic stroke. Significant associations were replicated in an independent sample of 843 IS cases and 933 controls from the UK. Results—Only one SNP (rs1048990 in PSMA6) showed association with overall IS, but this was not replicated in the UK sample. Three SNPs showed significant associations with stroke subtypes (P<0.05), but none of these associations could be replicated in the UK population. Conclusions—Genetic variation in the lymphotoxin-
Revised on February 8, 2008
Accepted on March 11, 2008
Genetic Variation in the Lymphotoxin-Alpha Pathway and the Risk of Ischemic Stroke in European Populations
Tobias Freilinger MD*;
cascade (LTA, LGALS2, and PSMA6) have been linked with the risk of myocardial infarction. Here, we present a comprehensive analysis of these genes in patients with ischemic stroke (IS). cascade (LTA, LGALS2, and PSMA6) is not a major risk factor for IS.
Key words: stroke • genetics • PSMA6 • LTA • LGALS2