Published Online
on July 24, 2008

A more recent version of this article appeared on October 1, 2008

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Submitted on December 3, 2007
Revised on January 22, 2008
Accepted on January 30, 2008

Blood Biomarkers in the Diagnosis of Ischemic Stroke. A Systematic Review

William Whiteley MRCP^*; Mei-Chiun Tseng PhD; and Peter Sandercock FRCPE

From the Division of Clinical Neurosciences (W.N.W., P.S.), University of Edinburgh, UK; and National Sun Yat-Sen University (M.-C.T.), Taiwan.

^* To whom correspondence should be addressed. E-mail: william.whiteley{at}ed.ac.uk.

Background and Purpose—The diagnosis of ischemic stroke can be difficult. CT may be normal in the early stages of ischemic stroke or in patients with minor symptoms and MR is not always possible. Many blood markers have been proposed for the diagnosis of stroke in the acute setting.

Methods and Results—We have systematically reviewed the diagnostic literature and found 21 studies testing 58 single biomarkers and 7 panels of several biomarkers. Although all show either a high sensitivity or specificity, there are limitations in the design and reporting of all the studies that mean no biomarker can be recommended for use in clinical practice.

Conclusions—We make recommendations for the design and reporting of studies of diagnostic blood biomarkers in stroke.

Key words: biomarker • stroke • hemorrhagic stroke • ischemic stroke • diagnosis

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