on August 7, 2008
Published online before print August 7, 2008, doi: 10.1161/STROKEAHA.107.511360
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Submitted on November 29, 2007
From the Departments of Neurosurgery (K.O., Y.S., K.C., M.K., K.Y., Y.O., A.O.), and Radiology (M.S.), School of Medicine, Iwate Medical University, Morioka, Japan. * To whom correspondence should be addressed. E-mail: kuogasa{at}iwate-med.ac.jp.
Background and Purpose—Microemboli generated during dissection of the carotid arteries in patients undergoing carotid endarterectomy result in postoperative cerebral ischemic events. The purpose of this study was to determine whether these events correlate with middle cerebral artery blood flow velocity. Methods—One hundred sixty-three patients with ipsilateral internal carotid artery stenosis (>70%) underwent carotid endarterectomy under transcranial Doppler monitoring of mean blood flow velocity and microembolic signals in the ipsilateral middle cerebral artery. Results—Logistic regression analysis of several variables demonstrated that only middle cerebral artery mean blood flow velocity during carotid dissection was significantly associated with new postoperative neurological deficits in patients with microembolic signals during carotid dissection (95% CI, 1.069 to 1.528; P=0.0072). The combination of low middle cerebral artery mean blood flow velocity ( Conclusions—Intraoperative microemboli and low middle cerebral artery mean blood flow velocity are additive in predicting the development of cerebral ischemic events after carotid endarterectomy.
Revised on February 22, 2008
Accepted on March 18, 2008
Intraoperative Microemboli and Low Middle Cerebral Artery Blood Flow Velocity Are Additive in Predicting Development of Cerebral Ischemic Events After Carotid Endarterectomy
Kuniaki Ogasawara MD*;
28 cm/s) and microembolic signals 
10 during carotid dissection resulted in improved specificity and positive predictive value for the development of new postoperative neurological deficits when compared with either criterion used alone.
Key words: carotid endarterectomy • diffusion-weighted imaging • flow velocity • microemboli • transcranial Doppler ultrasonography
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  A. King and H. S. Markus Doppler Embolic Signals in Cerebrovascular Disease and Prediction of Stroke Risk: A Systematic Review and Meta-Analysis * Supplemental Online References Stroke, December 1, 2009; 40(12): 3711 - 3717. [Abstract] [Full Text] [PDF]
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