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on September 4, 2008

Stroke. 2008
Published online before print September 4, 2008, doi: 10.1161/STROKEAHA.107.512996
A more recent version of this article appeared on December 1, 2008
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*Brain Aneurysm
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Submitted on December 21, 2007
Revised on January 18, 2008
Accepted on March 19, 2008

Stent-Assisted Reconstructive Endovascular Repair of Cranial Fusiform Atherosclerotic and Dissecting Aneurysms. Long-Term Clinical and Angiographic Follow-Up

Ajay K. Wakhloo MD, PhD*; Jake Mandell MD; Matthew J. Gounis PhD; Christopher Brooks PAC; Italo Linfante MD; Jesse Winer MD; and John P. Weaver MD

From the Division of Neuroimaging and Intervention, Departments of Radiology and Neurosurgery, University of Massachusetts Medical School, Worcester, Mass.

* To whom correspondence should be addressed. E-mail: wakhlooa{at}ummhc.org.

Background and Purpose—The purpose of this study was to investigate the periprocedural morbidity, mortality, and long-term clinical and angiographic follow-up using stent-assisted coiling and stenting alone for treatment of cranial fusiform dissecting and atherosclerotic aneurysms.

Methods—The Institutional Review Board approved the study. A retrospective analysis was performed of 30 fusiform dissecting and atherosclerotic aneurysms treated in 28 patients (20 females; mean age, 52.6 years). Eleven aneurysms (37%) were located in the posterior circulation. Twenty-one (70%) originated from arterial dissection and 4 aneurysms (13%) presented with subarachnoid bleeding. Twenty-four (80%) aneurysms were treated with stents and coils, whereas 6 (20%) were treated with stents alone.

Results—Immediate postprocedural angiograms in 24 aneurysms treated with stent-assisted coiling showed complete occlusion in 12 and subtotal occlusion in 11 aneurysms, whereas no occlusion was seen in one aneurysm and in all 6 aneurysms treated with stents alone. A clinical improvement or stable outcome was achieved in 25 patients (89%). The 2 cases of permanent morbidity included a patient with a finger dysesthesia associated with a perforator stroke and another patient with hemiparesis and aphasia due to a delayed in-stent thrombosis. One patient died after treatment of a giant vertebrobasilar junction aneurysm. Angiographic follow-up was available in 23 of the 27 surviving patients (85%) at a mean of 16.2 months (range, 1 to 108 months). Recanalization in 4 patients (17%) at 3, 5, 24, and 36 months required retreatment in 3. In-stent stenosis of ≤50% was found in 3 patients.

Conclusion—Stent-assisted coil embolization is an attractive option for ruptured and nonruptured fusiform aneurysms with stable long-term outcome. However, recanalization observed up to 3 years after the initial obliteration emphasizes the need for long-term follow-up angiography.


Key words: dissecting aneurysm • fusiform aneurysms • intracranial aneurysms • new endovascular techniques • pseudoaneurysms • stent-assisted coiling • stents




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