on November 6, 2008
Published online before print November 6, 2008, doi: 10.1161/STROKEAHA.108.526665
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Submitted on May 22, 2008
From Institute of Neuroscience (G.M.S., P.M.W.B., L.J.G., T.E., C.G.), University of Nottingham, Nottingham, UK; Stroke Unit (T.M.), CHU Besancon, University of Franche-Comte, Besancon, France; Department of Neurology (F.W.), Lariboisiere University Hospital, France; Department of Neurology (H.C.), Bispebjerg Hospital, Copenhagen, Denmark; Department of Neurology (P.P.D.D.), A. Z. Middelheim, ZNA, University of Antwerp, Antwerpen, Belgium; Clinique Neurologique (D.L.), CHRU de Lille, Lille, France; Department of Age Related Health Care (D.O.), Adelaide & Meath Hospital, Dublin, Ireland; Klinik für Neurologie (E.B.R.), Universität Münster, Münster, Germany. * To whom correspondence should be addressed. E-mail: philip.bath{at}nottingham.ac.uk.
Background and Purpose—High blood pressure (BP) is present in Methods—TAIST was a randomized controlled trial assessing 10 days of treatment with tinzaparin versus aspirin in 1489 patients with acute ischemic stroke (<48 hr) with admission BP of Results—Higher systolic BP (SBP) was associated with abnormal CT scans because of independent associations with chronic changes of leukoariosis (OR, 1.12; 95% CI, 1.05–1.17) and old infarction (OR, 1.12; 95% CI, 1.06–1.17) at baseline, and signs of visible infarction at day 10 (OR, 1.06; 95% CI, 1.00–1.13). A lower SBP was associated with signs of acute infarction (OR, 0.94; 95% CI, 0.89–0.99). Hemorrhagic transformation, dense middle cerebral artery sign, mass effect, and cerebral edema at day 10 were not independently associated with baseline BP. Conclusion—Although high baseline BP is independently associated with a poor outcome after stroke, this was not shown to be through an association with increased hemorrhagic transformation, cerebral edema, or mass effect; trial design may be suboptimal to detect this. Higher SBP is associated with visible infarction on day 10 scans. The influence of changing BP in acute stroke on CT findings is still to be ascertained.
Accepted on June 11, 2008
The Relationship Between Baseline Blood Pressure and Computed Tomography Findings in Acute Stroke. Data From the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
Gillian M. Sare MRCP;
80% of patients with acute ischemic stroke and is independently associated with poor outcome. There are few data examining the relationship between admission BP and acute CT findings.
220/120 mm Hg. CT brain scans were performed before randomization and after 10 days. The relationships between baseline BP and adjudicated CT findings were assessed. Odds ratios per 10 mm Hg change in BP were calculated.
Key words: acute stroke • CT • hypertension • ischaemia • outcome
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