Published Online
on December 12, 2008

A more recent version of this article appeared on March 1, 2009

This Article Full Text (PDF) All Versions of this Article: 40/3_suppl_1/S24    most recent STROKEAHA.108.526814v2 STROKEAHA.108.526814v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Soares, B. P. Articles by Wintermark, M. Search for Related Content PubMed PubMed Citation Articles by Soares, B. P. Articles by Wintermark, M. Related Collections CT and MRI Acute Cerebral Infarction Computerized tomography and Magnetic Resonance Imaging Thrombolysis

Submitted on May 25, 2008
Accepted on July 30, 2008

MR and CT Monitoring of Recanalization, Reperfusion, and Penumbra Salvage. Everything That Recanalizes Does Not Necessarily Reperfuse!

Bruno P. Soares MD; Jeffrey D. Chien BA; and Max Wintermark MD^*

From the Department of Radiology, Neuroradiology Section, University of California, San Francisco.

^* To whom correspondence should be addressed. E-mail: Max.Wintermark{at}radiology.ucsf.edu.

Abstract—Revascularization therapies for acute stroke patients aim to rescue the ischemic penumbra by restoring the patency of the occluded artery ("recanalization") and the downstream capillary blood flow ("reperfusion"). This article reviews the definition of recanalization and reperfusion used in stroke clinical trials and their limitations and proposes a study design to determine the relative importance of recanalization, reperfusion, and collateral flow in evaluating the efficacy of revascularization therapies for acute ischemic stroke.

Key words: brain infarction • brain ischemia • cerebral infarct • CT • magnetic resonance • neuroradiology • reprefusion • tPA

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