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Published Online
on December 8, 2008

Stroke. 2008
Published online before print December 8, 2008, doi: 10.1161/STROKEAHA.108.529800
A more recent version of this article appeared on March 1, 2009
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Submitted on June 24, 2008
Accepted on July 3, 2008

Combination Pharmacotherapy for Achievement and Maintenance of Vascular Patency

Arthur M. Pancioli MD*

From the Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio.

* To whom correspondence should be addressed. E-mail: arthur.pancioli{at}uc.edu.

Abstract—Acute ischemic stroke results from an abrupt interruption of focal cerebral blood flow. In the majority of cases, this interruption is caused by an acute thromboembolism. Arising from the clinical trials in acute myocardial infarction, combination pharmacotherapy is gaining significant interest as a potential method to improve current thrombolytic treatment in acute ischemic stroke. This article reviews the scientific rationale and available evidence for the potential options to improve current pharmacologic therapy for achieving and maintaining vascular patency in acute ischemic stroke.
Key words: reperfusion • pharmacotherapy • vascular patency






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