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Published Online
on December 8, 2008

Stroke. 2008
Published online before print December 8, 2008, doi: 10.1161/STROKEAHA.108.530576
A more recent version of this article appeared on March 1, 2009
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Submitted on July 3, 2008
Accepted on July 8, 2008

Use of Imaging in Restorative Stroke Trials

Steven C. Cramer MD*

From the Departments of Neurology and Anatomy & Neurobiology, University of California, Irvine.

* To whom correspondence should be addressed. E-mail: scramer{at}uci.edu.

Abstract—Restorative therapies aim to improve behavioral outcome after stroke by promoting repair and restoration. Measures of CNS injury and function might be useful to evaluate such therapies in a clinical trial, for example, by optimizing patient selection or treatment dose. These issues are considered in this review, with specific examples provided.
Key words: stroke • plasticity • recovery • brain mapping






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