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Published Online
on December 8, 2008

Stroke. 2008
Published online before print December 8, 2008, doi: 10.1161/STROKEAHA.108.533083
A more recent version of this article appeared on March 1, 2009
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Submitted on July 30, 2008
Accepted on August 6, 2008

Multimodal Neuroprotective Therapy With Induced Hypothermia After Ischemic Stroke

Thomas M. Hemmen MD, PhD* and Patrick D. Lyden MD, FAAN

From the Department of Neuroscience (T.M.H., P.D.L.), University of California, San Diego, San Diego, Calif; and the Department of Veterans' Affairs San Diego (P.D.L.), San Diego, Calif.

* To whom correspondence should be addressed. E-mail: themmen{at}ucsd.edu.

Abstract—Neuroprotective therapies have so far failed to provide improved neurological function and outcome after stroke. A recent focus on multimodal therapies, including the combination of neuroprotective medications with hypothermia, opens a promising new treatment strategy. Advances in hypothermia administration make it one of the most promising neuroprotective therapies available and an ideal candidate for combination with other neuroprotective approaches.
Key words: hypothermia • ischemia • neuroprotection






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