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Published Online
on December 8, 2008

Stroke. 2008
Published online before print December 8, 2008, doi: 10.1161/STROKEAHA.108.533141
A more recent version of this article appeared on March 1, 2009
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Submitted on July 30, 2008
Accepted on July 30, 2008

Mechanisms Underlying Improved Recovery of Neurological Function After Stroke in the Rodent After Treatment With Neurorestorative Cell-Based Therapies

Michael Chopp PhD*; Yi Li MD; and Zheng Gang Zhang MD, PhD

From the Department of Neurology (M.C., Y.L., Z.G.Z.), Henry Ford Hospital, Detroit; and the Department of Physics (M.C.), Oakland University, Rochester, Mich.

* To whom correspondence should be addressed. E-mail: chopp{at}neuro.hfh.edu.

Abstract—We discuss the mechanisms of action underlying the beneficial effects of treating ischemic stroke in the rodent with exogenously administered cells. The essential hypothesis proposed is that the administered cells enhance recovery of neurological function by stimulating the production of restorative factors by parenchymal cells. These activated endogenous brain cells evoke white matter remodeling in the brain and the spinal cord and generate microenvironments within the injured brain that amplify brain plasticity and lead to improvement in neurological function poststroke.
Key words: stroke • cell-based therapies • mechanisms • neurological function






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