Published Online
on December 8, 2008

A more recent version of this article appeared on March 1, 2009

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Submitted on August 11, 2008
Accepted on August 12, 2008

Cognition in CADASIL

Martin Dichgans MD^*

From the Department of Neurology, Ludwig-Maximilians-Universität, Klinikum Grohadern, München, Germany.

^* To whom correspondence should be addressed. E-mail: martin.dichgans{at}med.uni-muenchen.de.

Abstract—CADASIL is an early onset small vessel disease and genetic variant of pure subcortical ischemic vascular dementia (SIVD). The condition has been invaluable in defining the profile and neuroimaging correlates of cognitive deficits in pure SIVD. The recent completion of a randomized trial in cognitively impaired CADASIL patients has illustrated the feasibility of targeted therapeutic trials in narrowly defined subtypes of vascular cognitive impairment. This article highlights some of the advances on cognition in CADASIL.

Key words: CADASIL syndrome • genetics • lacunar infarcts • vascular cognitive impairment • vascular dementia • white matter disease • stroke

This article has been cited by other articles:

				S. Black and C. Iadecola Vascular Cognitive Impairment: Small Vessels, Big Toll: Introduction Stroke, March 1, 2009; 40(3_suppl_1): S38 - S39. [Full Text] [PDF]