Oxygen Availability in Ischemic Brain Following Hypocarbia and Hypercarbia
Polarographical Depth Electrode Recordings in Evolving and Completed Experimental Stroke in the Monkey
Acutely implanted oxygen-recording polarographical depth electrodes were used to appraise changes in oxygen availability (O2a) in the brain of the Rhesus monkey. Modifications of oxygen availability induced by hypocarbia and hypercarbia in the normal and the infarcted brain are described. The most consistent finding was a reversal of the expected effects of low and high Paco2 values during the acutely ischemic period (evolving stroke) and an incomplete return to the normal response by five days (completed stroke).
- polarographical electrodes
- experimental middle cerebral artery occlusion
- loss of autoregulation
- hyperventilation hypocapnia
- © 1972 American Heart Association, Inc.