An Analysis of Factors Associated with Early Intracerebral Hemorrhage (ICH) Growth
Introduction: Early hemorrhage growth and clinical deterioration has been shown to occur in at least 25% of patients with spontaneous ICH. This study investigated potential baseline clinical factors associated with early hemorrhage growth in spontaneous ICH patients. Methods: We performed a post-hoc analysis of a prospective observational study of patients with spontaneous ICH within 3 hours of onset. CT scans were performed at presentation and 1 hour. Demographic variables (diabetes, smoking, hypertension, alcohol use, and antiplatelet medication) and clinical variables [systolic and diastolic blood pressure (SDP, DBP), mean arterial pressure (MAP), pulse pressure(PP) and combinations of these with heart rate (HR)] were analyzed using univariate analyses. Principle components analysis and logistic regression modeling were also performed. Results: Complete data sets were available for 97 of the 103 patients. Univariate analyses of demographic and clinical variables failed to identify an association with those patients who experienced hemorrhage growth in the first hour of management. Multivariate and multivariable analyses similarly failed to identify factors associated with early hemorrhage growth (Table 1). Conclusion: No single demographic or clinical variable or combination increased risks of early hemorrhage growth. Specifically, no blood pressure or heart rate parameter, individually or in combination, were associated with early ICH growth.