The effect of platelet function abnormalities on the volume of spontaneous intracerebral hemorrhage(ICH)
Objectives: Impaired platelet function has been associated with increased propensity for ICH. Our objective is to demonstrate that patients with larger ICH volume have abnormal platelet function. Methods: This is a prospective cohort study. Platelet function was measured by a standard set of tests within one week of ICH. CT scans were performed within 24 hours of the event and ICH volume determined by the ABC/2 method. Results: 12 patients were enrolled (5/12 female, 7/12 male). The mean age was 64 years (range 40–85). Four patients were on ASA. Platelet count ranged from 76 to 315 KU/mm3. Patients were divided into two subgroups based on ICH size: ≤30cc and >30cc. The two CT subgroups were similar with respect to age, sex, race, history of hypertension and alcohol abuse. We report in Table 1 the distribution of specific platelet abnormalities among the two ICH groups. Conclusions: Large spontaneous ICH (>30cc) is associated with evidence of platelet hypoactivity which appear to extend beyong ASA effect.