Re: External Carotid Artery Territory Ischemia Impairs Outcome in the Endovascular Filament Model of Middle Cerebral Artery Occlusion in Rats
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To the Editor:
We read with interest the article by Dittmar et al1 on body weight loss after middle cerebral artery occlusion (MCAO) by the intraluminal filament method. The authors provided evidence that transection of the external carotid artery (ECA), which is necessary for thread insertion, produced ischemic tissue damage of the lingual and pharyngeal musculature leading to impaired mastication and swallowing functions and eventually loss of body weight. Loss of body weight, however, was also severe in rats subjected to MCAO with no evidence of damage in the ECA territory, suggesting that other factors are involved.
We have investigated whether dehydration, postoperative stress, or altered hormonal secretion contribute to body weight loss after 120 minutes MCAO (Figure).2 Based on plasma osmolality measurements (OSMOL), our rats were not dehydrated, perhaps due in part to the supplemental 0.9% NaCl given to the rats. Corticosterone levels (CORT) were increased only transiently after MCAO, indicating that extensive surgical procedures and postoperative stress do not contribute to weight loss. Unilateral damage to the hypothalamus is typical in MCAO rats and might contribute to postoperative hyperthermia,3 but according to …