In the article entitled “Genome-Wide Linkage in a Large Dutch Consanguineous Family Maps a Locus for Intracranial Aneurysms to Chromosome 2p13” by Roos et al,1 we described linkage of intracranial aneurysms to chromosome 2p13. Based on this publication the Online Mendelian Inheritance in Man (OMIM) database designated an entry as ANIB5.
However, repeated screening as part of a 5-year follow-up study of this family has revealed newly developed aneurysms in 2 siblings who previously had negative screenings. Another individual who previously was assigned as being affected (aneurysm suspected on MR angiography) was found to be unaffected on follow-up screening. Because the newly affected siblings did not carry the risk haplotype of chromosome 2p13, our previous results of positive linkage are no longer statistically significant. Based on the previous misclassification in this large consanguineous family, we decided to perform a new genome-wide linkage study in this family, using a model-free, nonparametric linkage, affecteds-only approach. A manuscript describing the results of this new linkage study is currently under consideration for publication in Stroke.
1 [Correction for Vol 35, Number 10, October 2004. Pages 2276–2281.]