Response to Letter by Markoula et al
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We have read with interest the results presented in Lazaros et al1 and discussed by Markoula et al2 on the relationship between risk of stroke and the genetic variations in the estrogen receptor α (ESR1), commonly known as the PvuII (−397T>C; rs2234693) and XbaI (−351A>G; rs9340799) polymorphisms. In correspondence with our findings3 they observed no such relationship in their primary analysis of 130 ischemic stroke patients versus 240 healthy age-matched controls. However, on additional analysis in smaller subgroups the authors report an association between the −351 (XbaI) A variant and earlier age at onset of stroke in males, and the …