Response to the Letter by Grond-Ginsbach et al
We appreciate the comments and interest of Grond-Ginsbach and colleagues regarding our article. As we remarked previously about another letter sent by the lead author1 commenting on our earlier article on the association between the H2 promoter haplotype of the GPx-3 gene and arterial ischemic stroke,2 it is difficult to know what to make of their results without the benefit of a rigorous peer review of the full study. The data presented in this letter, once again, lack the necessary detail and valid comparability to ascertain the generalizability of their analysis. We urge the authors to submit a formal manuscript on this analysis for full peer-review and publication for the benefit of the stroke and genetics communities.
Grond-Ginsbach C, Lichy C, Padovani A, Pezzini A. GPx-3 gene promoter variation and the risk of arterial ischemic stroke. Stroke. 2007; 38: e23; author reply e24.
Voetsch B, Jin RC, Bierl C, Benke KS, Kenet G, Simioni P, Ottaviano F, Damasceno BP, Annichino-Bizacchi JM, Handy DE, Loscalzo J. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke. 2007; 38: 41–49.