Response to Letter Regarding Article, “Arterial Stiffness and Cerebral Small Vessel Disease: The Rotterdam Scan Study”
To the Editor:
We thank Drs Saji and Kimura for their constructive comments that summarize our results with other pivotal studies on the same topic. The current literature indeed seems evident that arterial stiffness is associated with cerebral small vessel disease. One remark that we would like to add is that these data nicely illustrate the link between large vessel disease as operationalized by arterial stiffness of the aorta and small vessel disease, visualized as, white matter lesions, lacunar infarcts, and cerebral microbleeds. This suggests that there is no clear distinction between these 2 entities. Instead, these are 2 ends of the same spectrum, which may also explain the many shared risk factors.
Stroke welcomes Letters to the Editor and will publish them, if suitable, as space permits. Letters must reference a Stroke published-ahead-of-print article or an article printed within the past 3 weeks. The maximum length is 750 words including no more than 5 references and 3 authors. Please submit letters typed double-spaced. Letters may be shortened or edited. Include a completed copyright transfer agreement form (available online at http://stroke.ahajournals.org and http://submit-stroke.ahajournals.org).
- © 2012 American Heart Association, Inc.