Abstract 144: High Intake of Caffeine use in Protective in Survivors of Stroke and Myocardial Infarction: the results of Third National Health and Nutrition Examination Survey Mortality Follow-up Study.
BACKGROUND: Caffeine competitively inhibits different adenosine receptors and their associated G protein to relax smooth muscle, and stimulate the central nervous system and cardiac contractility. High long-term consumption is proposed to be associated with a lower risk of cardiovascular disease and diabetes mellitus. We performed this study to determine the effect of regular caffeine in survivors of cardiovascular events.
METHODS: We determined the association of caffeine use with stroke, acute MI, and cardiovascular disease related mortality and all-cause mortality in a nationally representative sample of 20 049 US adults aged 17 to 90 years who participated in the Third National Health and Nutrition Examination Survey Mortality Follow-up Study using Cox proportional hazards analyses. We categorized the participants based on total caffeine intake (by cups) determined by 24-hour dietary recall and each coffee cup was defined by 150-mg caffeine cup. We defined participants as nonusers if they responded to the caffeine use question as not used, as low intake users if they responded as using 1-2 cups per day, and as high intake users if they reported using 3 or more cups per day. Potential confounding factors in the association between caffeine use and outcome included age, sex, race/ethnicity, hypertension, hyperlipidemia, diabetes mellitus, cigarette smoking, body mass index, and alcohol use.
RESULTS: A total of 334 survivors with stroke, 624 survivors with MI and 115 with both stroke and MI were included in the analysis; 58 stroke related, 117 acute MI related, and 305 ischemic heart disease related deaths and 785 all causes deaths were reported during a mean follow-up period of 9.0+−5.2 years. After adjusting for differences in age, sex, race/ethnicity, hypertension, diabetes mellitus, hyperlipidemia, cigarette smoking, and alcohol use, persons who reported high intake of caffeine had a significantly lower likelihood of stroke related death (relative risk [RR], 0.3; 95% confidence interval [CI], 0.1 to 0.8) and ischemic heart disease related deaths (RR, 0.6; 95% CI, 0.4 to 0.99). After adjusting for potential confounders, persons who reported high intake caffeine use had also a significantly lower likelihood of cardiovascular deaths (RR, 0.5; 95% CI, 0.3 to 0.8) and all cause deaths (RR, 0.7; 95% CI, 0.5 to 0.9).
CONCLUSION: High intake of caffeine daily prominently reduced the stroke related mortality and also reduced to a lesser extent cardiovascular and all-cause mortality. Regular caffeine intake may represent an easy to implement secondary prevention strategy among survivors of MI and stroke
- © 2012 by American Heart Association, Inc.