Abstract 2574: Impact of Smoking Cessation on the Rish of Subarachnoid Hemorrhage: A Nationwide Multicenter Case-Control Study
Background: Subarachnoid hemorrhage (SAH) is the most devastating cerebrovascular disease. Cigarette smoking is one of the established risk factor for SAH, but on the relationship between smoking cessation, the risk of SAH has not been properly elucidated.
Methods: We performed a nationwide multicenter case-control study from 33 hospitals in Korea. A total of 426 SAH cases and 426 age and sex-matched controls were enrolled. The participants were asked about their smoking habits, including information about the amount and duration of smoking and the time at quitting smoking. The other data about life-style and medical history were also collected with structured questionnaires which trained interviewers administered.
Results: One-hundred forty eight SAH patients (37.4%) were current smokers compared with one-hundred three (24.2%) controls, giving an adjusted odds ratio of 2.84 (95% confidence interval, 1.63 to 4.97) after controlling possible confounders. According to cumulative dose of smoking (pack-years), the risk of SAH increases dose-dependently. Compared with current smokers, past smokers whose quitting duration was 5 or more years had a significant 59% reduced risk of SAH. However, previously heavy smokers (≥ 20 cigarettes per day) had a 2.3-times increased risk of SAH compared with never smokers.
Conclusion: The authors report that the cigarette smoking increases the risk of SAH dose-dependently. According to smoking cessation, stopping smoking may decrease the risk time-dependently, and this beneficial effect of smoking cessation could be decreased in previously heavy smokers. Our results suggest that the vigorous efforts to stop smoking should be performed to reduce the risk of SAH.
- © 2012 by American Heart Association, Inc.