Abstract 2939: Elevated Serum Soluble Lectin-like Oxidized Ldl Receptor-1(slox1)is Associated With Increased Ischemic Stroke Risk: A Case-control Study
BACKGROUND and PURPOSE: Lectin-like oxidized LDL receptor 1 (LOX-1) is responsible for uptake of oxidized LDL. LOX-1 is released to serum in part as the soluble form (sLOX-1). LOX-1 is reported to play crucial roles in the pathogenesis of atherosclerotic plaque rupture. We showed previously that high sLOX-1 could be a predictive biomarker for acute coronary syndrome. The aim of this study is to examine the impact of sLOX-1 on ischemic stroke risk.
METHODS: We enrolled consecutive 420 patients (257 men, 74±11 years) with ischemic stroke who were admitted to our hospital within 72 hours after the onset of stroke from August 2008 to August 2010. As healthy controls, we selected 1004 participants (430 men, 62±9.5 years) from the Suita Study,an population-based cohort in an urban area located same city with our hospital . As a baseline survey, we measured height, weight, BMI, drinking and smoking habits, history of hypertension, dyslipidemia and diabetes. We also obtained information of stroke subtypes from the case group. Morning blood samples after an overnight fast (within 72 hours after the onset in the case group) were used to evaluate sLOX-1. We measured sLOX-1 by using ELISAs with 2 monoclonal antibodies against LOX-1.
RESULTS: Cases were consisted of 61 atherothrombotic, 142 cardioembolic, 75 lacunar infarctions, and 142 others. The measurement ranges of sLOX-1 were 102 - 6,167 (mean 777, median 527 ) ng/L for the case group and 104 -12,142 (mean 623, median 481) ng/L for the control group. The odds ratio (95% confidence intervals; 95% CI) for the risk of stroke in the highest quartile of sLOX-1 as compared with the lowest quartile was 1.72 (1.10-2.69 p=0.015) for all ischemic strokes after adjusting for sex, age, BMI, drinking, smoking, hypertension, dyslipidemia and diabetes. The odds ratios (95% CI) for the risk of each ischemic stroke subtypes was 3.74 (1.41-10.4 p=0.008) for atherothrombotic, 2.38 (1.28-4.46 p=0.006) for cardioembolic, 1.82 (0.78-4.23 p=0.16) for lacunar, 0.76(0.47-1.26 p=0.29) for others, respectively.
CONCLUSIONS: Elevated sLOX-1 could predict the onset of ischemic stroke, especially for atherothrombotic and cardioembolic infarctions.
- © 2012 by American Heart Association, Inc.