Abstract 3171: Low Stroke Incidence In Asymptomatic Carotid Stenosis Under Optimal Risk Factor Control.
Background: benefits of interventional procedures for the treatment of asymptomatic carotid stenosis (ACS) are still under debate. Our objective was to evaluate the risk of vascular events in a cohort of patients with ACS under optimal medical treatment.
Methods: patients with ACS ≥50% were prospectively evaluated. Data on demographic and vascular risk factor profile and control under pharmacological treatment were collected. Severity of carotid stenosis was confirmed by at least two methods (Doppler ultrasonography, angioresonance, angiotomography or digital angiography) and evolution over time was evaluated by Doppler ultrasonography performed by the same operator, blinded to clinical data. Primary end-points were coronary events and ispsilateral ischemic stroke (IIS).
Results: ninety two patients were included between January 2007 and December 2010. Mean age was 72±8 years, 35% were women. Mayor vascular risk factors were: hypertension (97%), dyslipidemia (90%), obesity (40%), diabetes (30%), smoking or former smoking (51%), history of coronary heart disease (37%) and peripheral vascular disease (32%). Average follow-up was 667±509 days (range 180-1870 days). Table 1 shows vascular risk factor control during follow-up. One IIS (1.08%; 95% CI 0.19-5.9; 5.8/1000 person/year) and 2 acute myocardial infarction (2.17%; 95% CI 0.6-7.5; 11.73/1000 person/year) were observed. Eighteen percent of patients had stenosis 50-70%, 68% between 70-90% and 13% ≥ 90%. After one year most of patients showed no changes in stenosis severity (76%), 5.56% had progression and 6.52% had regression; 14.1% had no control.
Conclusion: optimal pharmacological treatment was related to a very low incidence of vascular events. These data reassert the efficacy of intensive medical treatment in delaying atherosclerotic plaque progression and carotid disease complications.
- © 2012 by American Heart Association, Inc.