Abstract 3332: Common Carotid Intima Media Thickness, Carotid Plaque and Cognitive Performance in Patients with Atherosclerotic Disease
Background- Patients with atherothrombotic disease are prone to cognitive impairment. We tested whether high common carotid intima-media thickness (CC-IMT) and bilateral carotid plaques among patients with long lasting CHD are associated with poorer cognitive scores.
Methods- Patients with CHD previously included in a secondary prevention trial were assessed after a period of 15±3 years for cognitive performance (Mindstream Computerized Cognitive Battery), for CC-IMT (M’Ath®-Std, Metris) and for carotid plaque using ultrasound (HDI 5000 SonoCT, Philips). We compared cognitive scores in patients with and without high CC-IMT values (top quartile of CC- IMT; >1.06 mm) and in patients with and without high CC-IMT and bilateral carotid plaques.
Results - Among 448 non-demented patients (mean age 71.8±6.1 yrs, 96% men) mean±SD CC-IMT was 0.97±0.17 and 54.7% had bilateral carotid plaques. Linear regression models (Table) adjusted for age, sex, education, BMI, smoking, diabetes and hypertension (Model 1) demonstrated that high CC-IMT and presence of high CC-IMT and carotid plaques were associated with lower cognitive scores. Additional adjustment for history of stroke and impaired cerebrovascular reactivity (Model 2) resulted in similar effects. Associations were only slightly altered after exclusion of patients with history of stroke.
Conclusion- Among non-demented patients with long lasting CHD, high CC- IMT and presence of high CC-IMT and carotid plaques are associated with lower cognitive performance particularly in the executive function domain.
- © 2012 by American Heart Association, Inc.